BU 224 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BU 224 hydrochloride is a selective imidazoline I(2) binding site ligand and has antinociceptive and antidepressant-like activities.

BU 224 hydrochloride is a selective imidazoline I(2) binding site ligand and has antinociceptive and antidepressant-like activities.(In Vivo):BU 224 hydrochloride (5 mg/kg; i.p.) attenuated spatial and perirhinal cortex-dependent recognition memory deficits in 5XFAD mice. Fear-conditioning testing revealed that BU 224 hydrochloride also improved both associative learning and hippocampal- and amygdala-dependent memory in transgenic but not in WT mice. In the brain, BU 224 hydrochloride reduced levels of the microglial marker Iba1 and pro-inflammatory cytokines IL-1β and TNF-α and increased the expression of astrocytic marker GFAP in 5XFAD mice.

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Others

Other Targets

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205437-64-5

233.7

C12H12ClN3

>98% (HPLC)

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C1CN=C(N1)C2=NC3=CC=CC=C3C=C2.Cl

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(-20℃)

With Ice Pack

≥ 2 years