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BU 224 hydrochloride

CAS No. 205437-64-5

BU 224 hydrochloride ( —— )

产品货号. M27501 CAS No. 205437-64-5

BU 224 盐酸盐是一种选择性咪唑啉 I(2) 结合位点配体,具有镇痛和抗抑郁样活性。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥389 有现货
5MG ¥648 有现货
10MG ¥988 有现货
25MG ¥2130 有现货
50MG ¥3418 有现货
100MG ¥4949 有现货
500MG ¥10449 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    BU 224 hydrochloride
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    BU 224 盐酸盐是一种选择性咪唑啉 I(2) 结合位点配体,具有镇痛和抗抑郁样活性。
  • 产品描述
    BU 224 hydrochloride is a selective imidazoline I(2) binding site ligand and has antinociceptive and antidepressant-like activities.(In Vivo):BU 224 hydrochloride (5 mg/kg; i.p.) attenuated spatial and perirhinal cortex-dependent recognition memory deficits in 5XFAD mice. Fear-conditioning testing revealed that BU 224 hydrochloride also improved both associative learning and hippocampal- and amygdala-dependent memory in transgenic but not in WT mice. In the brain, BU 224 hydrochloride reduced levels of the microglial marker Iba1 and pro-inflammatory cytokines IL-1β and TNF-α and increased the expression of astrocytic marker GFAP in 5XFAD mice.
  • 体外实验
    ——
  • 体内实验
    BU224 hydrochloride (5 mg/kg, IP, twice a day for 10 days) improves behavioural performance and memory function in 5XFAD mice.BU224 hydrochloride (5 mg/kg, IP, twice a day for 10 days) reduces levels of the microglial marker Iba1 and pro-inflammatory cytokines IL-1β and TNF-α and increased the expression of astrocytic marker GFAP in 5XFAD mice.BU224 hydrochloride (10 mg/kg, IP, once) reduces immobility of rats in the FST (forced swim test), indicative of antidepressant-like activity. Animal Model:5XFAD mice and and WT littermates (6-month-old) Dosage:0 mg/kg, 5 mg/kgAdministration:IP, twice a day for 10 daysResult:Significantly increased immobility (54% increased freezing), and reversed memory deficits secondary to the deposition of Aβ in the brain.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    ——
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    205437-64-5
  • 分子量
    233.69
  • 分子式
    C12H12ClN3
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 12.5 mg/mL (53.49 mM)
  • SMILES
    C1CN=C(N1)C2=NC3=CC=CC=C3C=C2.Cl
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Mahanta S, et al. Sour beer production in India using a coculture of Saccharomyces pastorianus and Lactobacillus plantarum: optimization, microbiological, and biochemical profiling. Braz J Microbiol. 2022 Jun;53(2):947-958.
产品手册
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