
BU 224 hydrochloride
CAS No. 205437-64-5
BU 224 hydrochloride ( —— )
产品货号. M27501 CAS No. 205437-64-5
BU 224 盐酸盐是一种选择性咪唑啉 I(2) 结合位点配体,具有镇痛和抗抑郁样活性。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥389 | 有现货 |
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5MG | ¥648 | 有现货 |
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10MG | ¥988 | 有现货 |
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25MG | ¥2130 | 有现货 |
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50MG | ¥3418 | 有现货 |
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100MG | ¥4949 | 有现货 |
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500MG | ¥10449 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称BU 224 hydrochloride
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述BU 224 盐酸盐是一种选择性咪唑啉 I(2) 结合位点配体,具有镇痛和抗抑郁样活性。
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产品描述BU 224 hydrochloride is a selective imidazoline I(2) binding site ligand and has antinociceptive and antidepressant-like activities.(In Vivo):BU 224 hydrochloride (5 mg/kg; i.p.) attenuated spatial and perirhinal cortex-dependent recognition memory deficits in 5XFAD mice. Fear-conditioning testing revealed that BU 224 hydrochloride also improved both associative learning and hippocampal- and amygdala-dependent memory in transgenic but not in WT mice. In the brain, BU 224 hydrochloride reduced levels of the microglial marker Iba1 and pro-inflammatory cytokines IL-1β and TNF-α and increased the expression of astrocytic marker GFAP in 5XFAD mice.
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体外实验——
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体内实验BU224 hydrochloride (5 mg/kg, IP, twice a day for 10 days) improves behavioural performance and memory function in 5XFAD mice.BU224 hydrochloride (5 mg/kg, IP, twice a day for 10 days) reduces levels of the microglial marker Iba1 and pro-inflammatory cytokines IL-1β and TNF-α and increased the expression of astrocytic marker GFAP in 5XFAD mice.BU224 hydrochloride (10 mg/kg, IP, once) reduces immobility of rats in the FST (forced swim test), indicative of antidepressant-like activity. Animal Model:5XFAD mice and and WT littermates (6-month-old) Dosage:0 mg/kg, 5 mg/kgAdministration:IP, twice a day for 10 daysResult:Significantly increased immobility (54% increased freezing), and reversed memory deficits secondary to the deposition of Aβ in the brain.
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同义词——
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number205437-64-5
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分子量233.69
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分子式C12H12ClN3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 12.5 mg/mL (53.49 mM)
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SMILESC1CN=C(N1)C2=NC3=CC=CC=C3C=C2.Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Mahanta S, et al. Sour beer production in India using a coculture of Saccharomyces pastorianus and Lactobacillus plantarum: optimization, microbiological, and biochemical profiling. Braz J Microbiol. 2022 Jun;53(2):947-958.
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